Can Jaundice Cause Autism

December 16, 2025

The question of whether jaundice causes autism has been explored in several research studies with mixed results. Some studies have found a statistical association between severe neonatal jaundice and slightly increased autism risk, while others have not. Here is what parents should know.

What Research Shows

A meta-analysis of available studies found a modest association between neonatal jaundice (hyperbilirubinemia) and autism. However, the relationship is complex. Severe, untreated jaundice can cause a condition called kernicterus, which damages the brain and can lead to developmental disabilities. Modern screening and treatment have made kernicterus extremely rare.

Important Context

  • Mild jaundice is extremely common, affecting about 60% of newborns
  • Most jaundice resolves on its own or with phototherapy
  • Only severe, untreated jaundice poses developmental risks
  • The association may be due to shared risk factors rather than direct causation

What Parents Should Do

Follow your pediatrician s recommendations for jaundice monitoring and treatment. Routine newborn screening catches jaundice early, and modern treatment is highly effective at preventing complications.

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